Sites % in DHSs Enrichment for DHSs Mean MAF Median distance to nearest TSS (kb) Mean %CG (±10bp) % in introns %Intronic sites in DHSs Random 36mer-mappable sites 0.411 1.00 NA 71.4 40.16 0.367 47.50% 1000 Genomes CEU SNPs 0.429 1.04 0.18 77.7 41.01 0.359 49.60% HapMap CEU SNPs 0.465 1.13 0.22 84.1 40.95 0.377 52.90% Affymetrix 500k SNPs 0.497 1.21 0.23 82.2 40.85 0.375 55.90% Unreplicated GWAS SNPs 0.532 1.29 0.24 57.0 41.66 0.402 60.30% Internally replicated GWAS SNPs 0.595 1.45 0.28 31.4 42.97 0.452 61.90% Externally replicated GWAS SNPs 0.698 1.70 0.28 24.1 43.21 0.481 71.20% All GWAS SNPs 0.571 1.39 0.26 40.7 42.36 0.43 0.62