Cell_line Description Fetal_origin #DHSs #GWAS_SNPs_in_DHSs Protocol A549 Epithelial cell line derived from a lung carcinoma tissue N "117,992" 180 genome.ucsc.edu/ENCODE/protocols/cell/human/A549_Stam_protocol.pdf AG04449 Fetal buttock/thigh fibroblast Y "174,802" 202 genome.ucsc.edu/ENCODE/protocols/cell/human/AG04449_Stam_protocol.pdf AG04450 Fetal lung fibroblast Y "150,114" 187 genome.ucsc.edu/ENCODE/protocols/cell/human/AG04450_Stam_protocol.pdf AG09309 Adult human toe fibroblast N "197,301" 266 genome.ucsc.edu/ENCODE/protocols/cell/human/AG09309_Stam_protocol.pdf AG09319 Adult human gum tissue fibroblasts N "137,192" 190 genome.ucsc.edu/ENCODE/protocols/cell/human/AG09319_Stam_protocol.pdf AG10803 Adult human abdominal skin fibroblasts N "171,903" 224 genome.ucsc.edu/ENCODE/protocols/cell/human/AG10803_Stam_protocol.pdf AoAF Normal Human Aortic Adventitial Fibroblast Cells N "169,477" 261 genome.ucsc.edu/ENCODE/protocols/cell/human/AoAF_Stam_protocol.pdf BE2_C Human Neuroblastoma cell line N "168,003" 259 genome.ucsc.edu/ENCODE/protocols/cell/human/BE2-C_Stam_protocol.pdf BJ Skin fibroblasts N "162,671" 246 genome.ucsc.edu/ENCODE/protocols/cell/human/BJ-tert_Stam_protocol.pdf Caco-2 Colorectal adenocarcinoma N "117,293" 179 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf CD14+ "Monocytes, CD14+" N "117,181" 273 genome.ucsc.edu/ENCODE/protocols/cell/human/MonoCD14_Stam_protocol.pdf CD19+ "Monocytes, CD19+" N "75,086" 225 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/HematopoieticCells_DNaseTreatment_V5_UW-NREMC.pdf CD20+ "B-lymphocytes, CD20+" N "170,412" 328 genome.ucsc.edu/ENCODE/protocols/cell/human/CD20+_Stam_protocol.pdf CD20+ "B-lymphocytes, CD20+" N "86,908" 268 genome.ucsc.edu/ENCODE/protocols/cell/human/CD20+_Stam_protocol.pdf CD3+ "T-lymphocytes, CD3+" N "77,933" 177 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/HematopoieticCells_DNaseTreatment_V5_UW-NREMC.pdf CD34+ Mobilized hematopoietic progenitor cells N "134,718" 230 genome.ucsc.edu/ENCODE/protocols/cell/human/CD34+Mobilized_Stam_protocol.pdf CD3+_CordBlood "Cord blood, CD3+" N "74,992" 176 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/HematopoieticCells_DNaseTreatment_V5_UW-NREMC.pdf CD4+ "T helper cells, CD4+" N "94,881" 239 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/HematopoieticCells_DNaseTreatment_V5_UW-NREMC.pdf CD56+ "Monocytes, CD56+" N "105,724" 277 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/HematopoieticCells_DNaseTreatment_V5_UW-NREMC.pdf CD8+ "Cytotoxic T cells, CD8+" N "75,382" 185 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/HematopoieticCells_DNaseTreatment_V5_UW-NREMC.pdf CMK Acute megakaryocytic leukemia cells N "123,561" 210 genome.ucsc.edu/ENCODE/protocols/cell/human/CMK_Stam_protocol.pdf GM06990 Lymphoblastoid N "86,958" 210 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf GM12864 Lymphoblastoid N "132,370" 262 genome.ucsc.edu/ENCODE/protocols/cell/human/GM12864_Stam_protocol.pdf GM12865 Lymphoblastoid N "133,962" 280 genome.ucsc.edu/ENCODE/protocols/cell/human/GM12865_Stam_protocol.pdf GM12878 Lymphoblastoid N "109,419" 240 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf H1_P18 H1-derived embryonic stem cells - "178,572" 255 "Yu et al., Cell Stem Cell 8, 326-334 (2011)" H7-hESC Undifferentiated embryonic stem cells - "284,627" 305 genome.ucsc.edu/ENCODE/protocols/cell/human/H7-hESC_Stam_protocol.pdf H9_P42 H9-derived embryonic stem cells - "140,166" 192 "Yu et al., Cell Stem Cell 8, 326-334 (2011)" HAEpiC Human Amniotic Epithelial Cells Y "200,771" 292 genome.ucsc.edu/ENCODE/protocols/cell/human/HAEpiC_Stam_protocol.pdf HAc Human Astrocytes - cerebellar Y "183,752" 239 genome.ucsc.edu/ENCODE/protocols/cell/human/HAc_Stam_protocol.pdf HAh Human Astrocytes - hippocampal Y "215,151" 351 genome.ucsc.edu/ENCODE/protocols/cell/human/HAh_Stam_protocol.pdf HAsp Human Astrocytes - Spinal cord Y "215,720" 350 genome.ucsc.edu/ENCODE/protocols/cell/human/HA-sp_Stam_protocol.pdf HBMEC Human Brain Microvascular Endothelial Cells Y "196,870" 320 genome.ucsc.edu/ENCODE/protocols/cell/human/HBMEC_Stam_protocol.pdf HCF Human Cardiac Fibroblasts Y "171,858" 268 genome.ucsc.edu/ENCODE/protocols/cell/human/HCF_Stam_protocol.pdf HCFaa Human Cardiac Fibroblasts - adult atrial N "184,810" 323 genome.ucsc.edu/ENCODE/protocols/cell/human/HCFaa_Stam_protocol.pdf HCM Human Cardiomyocytes Y "191,262" 308 genome.ucsc.edu/ENCODE/protocols/cell/human/HCM_Stam_protocol.pdf HCPEpiC Human Choroid Plexus Epithelial Cells Y "209,492" 304 genome.ucsc.edu/ENCODE/protocols/cell/human/HCPEpiC_Stam_protocol.pdf HCT-116 Colon adenocarcinoma N "104,196" 170 genome.ucsc.edu/ENCODE/protocols/cell/human/HCT116_Stam_protocol.pdf HConF Human Conjunctival Fibroblasts Y "150,877" 209 genome.ucsc.edu/ENCODE/protocols/cell/human/HConF_Stam_protocol.pdf HEEpiC Human Esophageal Epithelial Cells Y "213,954" 266 genome.ucsc.edu/ENCODE/protocols/cell/human/HEEpiC_Stam_protocol.pdf HepG2 Hepatocellular carcinoma N "81,159" 133 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf HESC Human H1 Embryonic Stem Cell line - "163,880" 195 genome.ucsc.edu/ENCODE/protocols/cell/human/HHSEC_Stam_protocol.pdf HFF Human Foreskin Fibroblasts N "189,148" 329 genome.ucsc.edu/ENCODE/protocols/cell/human/HFF_Stam_protocol.pdf HFF_Myc Human Foreskin Fibroblasts_Myc Transgene N "215,171" 333 genome.ucsc.edu/ENCODE/protocols/cell/human/HFFMyc_Stam_protocol.pdf HGF Human Gingival Fibroblasts N "148,852" 191 genome.ucsc.edu/ENCODE/protocols/cell/human/HGF_Stam_protocol.pdf HIPEpiC Human Iris Pigment Epithelial Cells Y "231,963" 304 genome.ucsc.edu/ENCODE/protocols/cell/human/HIPEpiC_Stam_protocol.pdf HL-60 Human promyelocyticleukemia cells N "153,865" 296 genome.ucsc.edu/ENCODE/protocols/cell/human/HL-60_Stam_protocol.pdf HMEC Human mammary epithelial cells N "139,620" 214 genome.ucsc.edu/ENCODE/protocols/cell/human/HMEC_Stam_protocol.pdf HMF Human Mammary Fibroblasts N "176,102" 236 genome.ucsc.edu/ENCODE/protocols/cell/human/HMF_Stam_protocol.pdf HMVEC-LBl Human Lung Blood Microvascular Endothelial Cells N "161,548" 283 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVEC-LBl_Stam_protocol.pdf HMVEC-LLy Human Lung Lymphatic Microvascular Endothelial Cells N "130,544" 235 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVEC-LLy_Stam_protocol.pdf HMVEC-dAd Adult Human Dermal Microvascular Endothelial Cells N "115,973" 175 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVECdAd_Stam_protocol.pdf HMVEC-dBl-Ad Adult Human Dermal Blood Microvascular Endothelial Cells N "149,796" 268 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVEC-dBl-Ad_Stam_protocol.pdf HMVEC-dBl-Neo Neonatal Human Dermal Blood Microvascular Endothelial Cells N "154,291" 310 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVEC-dBl-Neo_Stam_protocol.pdf HMVEC-dLy-Ad Adult Human Dermal Lymphatic Microvascular Endothelial Cells N "115,834" 194 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVEC-dLy-Ad_Stam_protocol.pdf HMVEC-dLy-Neo Neonatal Human Dermal Lymphatic Microvascular Endothelial Cells N "139,708" 242 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVEC-dLy-Neo_Stam_protocol.pdf HMVEC-dNeo Neonatal Human Dermal Microvascular Endothelial Cells N "132,325" 215 genome.ucsc.edu/ENCODE/protocols/cell/human/HMVEC-dNeo_Stam_protocol.pdf HNPCEpiC Human Non-Pigment Ciliary Epithelial Cells Y "217,558" 296 genome.ucsc.edu/ENCODE/protocols/cell/human/HNPCEpiC_Stam_protocol.pdf HPAEC Human Pulmonary Artery Endothelial Cells N "125,462" 170 genome.ucsc.edu/ENCODE/protocols/cell/human/HPAEC_Stam_protocol.pdf HPAF Human Pulmonary Artery Fibroblasts Y "181,244" 302 genome.ucsc.edu/ENCODE/protocols/cell/human/HPAF_Stam_protocol.pdf HPF Human Pulmonary Fibroblasts Y "147,153" 225 genome.ucsc.edu/ENCODE/protocols/cell/human/HPF_Stam_protocol.pdf HPdLF Human Periodontal Ligament Fibroblasts N "169,679" 260 genome.ucsc.edu/ENCODE/protocols/cell/human/HPdLF_Stam_protocol.pdf HRCEpiC Human renal cortical epithelial cells (normal) N "193,462" 294 genome.ucsc.edu/ENCODE/protocols/cell/human/HRCEpiC_Stam_protocol.pdf HRE Human renal epithelial cells (normal) N "197,779" 257 genome.ucsc.edu/ENCODE/protocols/cell/human/HRE_Stam_protocol.pdf HRGEC Human Renal Glomerular Endothelial Cells Y "143,319" 188 genome.ucsc.edu/ENCODE/protocols/cell/human/HRGEC_Stam_protocol.pdf HRPEpiC Human Retinal Pigment Epithelial Cells Y "229,606" 298 genome.ucsc.edu/ENCODE/protocols/cell/human/HRPEpiC_Stam_protocol.pdf HSMM Human Skeletal Muscle Myoblasts N "234,182" 335 genome.ucsc.edu/ENCODE/protocols/cell/human/HSMM_Stam_protocol.pdf HSMM_D Human Skeletal Muscle Myoblasts_differentiated N "233,756" 414 genome.ucsc.edu/ENCODE/protocols/cell/human/HSMM_Stam_protocol.pdf HUVEC Human umbilical vein endothelial cells N "115,081" 229 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf HVMF Human Villous Mesenchymal Fibroblasts Y "170,308" 296 genome.ucsc.edu/ENCODE/protocols/cell/human/HVMF_Stam_protocol.pdf HeLa-S3 Cervical carcinoma N "119,081" 247 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf IMR90 Fibroblasts N "196,940" 278 genome.ucsc.edu/ENCODE/protocols/cell/human/IMR90_Stam_protocol.pdf Jurkat T lymphoblastoid cell line derived from acute T cell leukemia N "152,487" 251 genome.ucsc.edu/ENCODE/protocols/cell/human/Jurkat_Stam_protocol.pdf K562 Chronic myeloid leukemia N "142,920" 268 N/A LNCaP Prostate adenocarcinoma cell line N "184,899" 239 genome.ucsc.edu/ENCODE/protocols/cell/human/LNCaP_Stam_protocol.pdf MCF-7 Mammary gland adenocarcinoma N "133,229" 168 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf Mesendoderm H1 derived mesendoderm cells - "214,950" 273 "Vodyanik et al., Cell Stem Cell 7, 718-729 (2010)" NB4 Acute Promyelocytic Leukemia cell line N "131,948" 240 genome.ucsc.edu/ENCODE/protocols/cell/human/NB4_Stam_protocol.pdf NH-A Normal Human Astrocytes Y "189,150" 280 genome.ucsc.edu/ENCODE/protocols/cell/human/NHA_Stam_protocol.pdf NHDF-Ad Adult Human Dermal Fibroblasts N "226,683" 330 genome.ucsc.edu/ENCODE/protocols/cell/human/NHDF-Ad_Stam_protocol.pdf NHDF-neo Neonatal Human Dermal Fibroblasts N "184,888" 269 genome.ucsc.edu/ENCODE/protocols/cell/human/NHDF-neo_Stam_protocol.pdf NHEK Normal Human Epidermal Keratinocytes N "145,886" 216 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf NHLF Normal Human Lung Fibroblasts N "204,839" 296 genome.ucsc.edu/ENCODE/protocols/cell/human/NHLF_Stam_protocol.pdf NPC H1 derived neuroprogenitor cells - "93,396" 148 N/A NT2-D1 Human malignant pluripotent embryonal cancer cell line - Induced by RA to neuronal cells N "187,959" 259 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf PANC-1 Pancreatic carcinoma cell line N "117,169" 203 genome.ucsc.edu/ENCODE/protocols/cell/human/PANC-1_Stam_protocol.pdf PrEC Human Prostate Epithelial Cell Line N "176,183" 220 genome.ucsc.edu/ENCODE/protocols/cell/human/PrEC_Stam_protocol.pdf RPTEC Human Renal Proximal Tubule Cells N "171,601" 293 genome.ucsc.edu/ENCODE/protocols/cell/human/RPTEC_Stam_protocol.pdf SAEC Small airway epithelial cells N "195,662" 279 genome.ucsc.edu/ENCODE/protocols/cell/human/SAEC_Stam_protocol.pdf SK-N-SH_RA Neuroblastoma cell lines differentiated with retinoic acid N "78,279" 99 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf SK_N_MC Neuroepithelioma cell line derived from a metastatic supra-orbital human brain tumor N "154,275" 177 genome.ucsc.edu/ENCODE/protocols/cell/human/SK-N-MC_Stam_protocol.pdf SKMC Human skeletal muscle cells Y "208,844" 274 genome.ucsc.edu/ENCODE/protocols/cell/human/SkMC_Stam_protocol.pdf Skin_Fibroblasts "Foreskin-derived fibroblasts, 4 samples" N "273,426" 507 N/A Skin_Keratinocytes "Foreskin-derived Keratinocytes, 4 samples" N "246,119" 461 N/A Skin_Melanocytes "Foreskin-derived melanocytes, 2 samples" N "205,035" 396 N/A Trophoblast H1 derived trophoblasts - "145,534" 181 N/A WERI-Rb-1 Retinoblastoma cell line N "190,883" 257 genome.ucsc.edu/ENCODE/protocols/cell/human/WERI-Rb-1_Stam_protocol.pdf WI-38 Embryonic lung fibroblasts immortilized hTERT Y "164,321" 252 genome.ucsc.edu/ENCODE/protocols/cell/human/WI38_Stam_protocol.pdf WI-38_TAM Embryonic lung fibroblasts immortilized hTERT_Tamoxifin treated Y "206,929" 358 genome.ucsc.edu/ENCODE/protocols/cell/human/WI38_Stam_protocol.pdf fAdrenal "Fetal adrenal tissue, 5 samples, ages 7-12 weeks" Y "282,181" 480 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_Human__tissue_DouncingV4_UW-NREMC.pdf fBrain "Fetal brain tissue, 12 samples, ages 12-20 weeks" Y "441,136" 621 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_Human__tissue_DouncingV4_UW-NREMC.pdf fHeart "Fetal heart tissue, 12 samples, ages 13-21 weeks" Y "393,615" 743 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_human__tissue-gentleMACS_V5_UW-NREMC.pdf fIntestine_Lg "Fetal large-intestine tissue, 15 samples, ages 12-16 weeks" Y "439,553" 839 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_human__tissue-gentleMACS_V5_UW-NREMC.pdf fIntestine_Sm "Fetal small-intestine tissue, 13 samples, ages 12-16 weeks" Y "360,316" 735 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_human__tissue-gentleMACS_V5_UW-NREMC.pdf fKidney "Fetal kidney tissue, 47 samples, ages 12-21 weeks" Y "666,350" 1124 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_Human__tissue_DouncingV4_UW-NREMC.pdf fLung "Fetal lung tissue, 34 samples, ages 10-17 weeks" Y "442,491" 917 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_Human__tissue_DouncingV4_UW-NREMC.pdf fMuscle "Fetal muscle tissue, 48 samples, ages 12-18 weeks" Y "632,517" 1176 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_human__tissue-gentleMACS_V5_UW-NREMC.pdf fPlacenta "Placenta tissue, 4 samples, ages 12-15 weeks" Y "281,754" 553 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_human__tissue-gentleMACS_V5_UW-NREMC.pdf fSkin "Fetal fibroblasts, 17 samples, ages 12-14 weeks" Y "392,999" 591 N/A fSpinal_cord "Fetal spinal-cord tissue, 3 samples, ages 12-16 weeks" Y "320,476" 554 "roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_human__tissue-gentleMACS_V5_UW-NREMC.pdf, but with gentleMACSDissociator Program ""B.01 C Tube""" fSpleen "Fetal spleen tissue, age 16 weeks" Y "175,572" 334 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_Human__tissue_DouncingV4_UW-NREMC.pdf fStomach "Fetal stomach tissue, 11 samples, ages 13-21 weeks" Y "346,348" 658 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_human__tissue-gentleMACS_V5_UW-NREMC.pdf fTestes "Fetal testicle tissue, age 16 weeks" Y "170,843" 309 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_Human__tissue_DouncingV4_UW-NREMC.pdf fThymus "Fetal thymus tissue, 10 samples, ages 12-21 weeks" Y "341,548" 658 roadmapepigenomics.org/files/protocols/experimental/dnaseI-sensitivity/Nuclei_isolation_DNase_Treatment_Human__tissue_DouncingV4_UW-NREMC.pdf Th1 Human primary T helper 1 cells N "70,474" 141 N/A Th1 Human primary T helper 1 cells N "73,754" 190 genome.ucsc.edu/ENCODE/protocols/cell/human/Stam_15_protocols.pdf Th17 Human primary T helper 17 cells N "78,543" 130 N/A Th2 Human primary T helper 2 cells N "111,450" 220 N/A Th2 Human primary T helper 2 cells N "80,196" 201 genome.ucsc.edu/ENCODE/protocols/cell/human/Th2_Stam_protocol.pdf iPS_19_11 Induced pluripotent stem cells - "204,668" 215 "Yu et al., Cell Stem Cell 8, 326-334 (2011)" iPS_19_7 Induced pluripotent stem cells - "185,193" 199 "Yu et al., Cell Stem Cell 8, 326-334 (2011)" iPS_4_7 Induced pluripotent stem cells - "193,671" 226 "Yu et al., Cell Stem Cell 8, 326-334 (2011)" iPS_6_9 Induced pluripotent stem cells - "191,788" 239 "Yu et al., Cell Stem Cell 8, 326-334 (2011)" vHMEC Human Mammary Epithelial Cells N "161,796" 272 N/A